Synthetic approaches to the 2012 new drugs

Bioorg Med Chem. 2014 Apr 1;22(7):2005-32. doi: 10.1016/j.bmc.2014.02.017. Epub 2014 Feb 25.

Abstract

New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011.

Keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents.

Publication types

  • Review

MeSH terms

  • Molecular Structure
  • Pharmaceutical Preparations / chemical synthesis*
  • Pharmaceutical Preparations / chemistry

Substances

  • Pharmaceutical Preparations